Influence of induced diabetes mellitus on hormonal profile of Lewis lung carcinoma in BALB/c Nude mice

Purpose of the study. The assessment diabetes mellitus (DM) effect on levels sex hormones in tumor and peritumoral tissues BALB/c Nude mice with Lewis lung carcinoma (LLC). Materials methods . study included 42 male female aged 8–9 weeks weighing 21–22 g. Alloxan-induced DM was reproduced main group, then LLC transplanted. Levels estrone (E1), estradiol (E2), testosterone (T), progesterone (P4) prolactin (PRL), as well steroid hormone receptors: estrogens (REα, REβ), androgens (RA), (RP4) were measured by RIA ELISA samples tissues. Animals without used controls. statistical analysis performed using Statistica 10 program; differences considered significant at p < 0.05. Results. males only after a double injection alloxan, characterized lower blood glucose compared to females. growth animals alloxan-induced possible mice; males, could not be transplanted either independently or combination DM. Females group showed greater average volumes throughout experiment reduced survival, control group. Tumor from females LLC+DM more saturated steroids, but depleted receptors, which probably contributed ability avoid body's regulatory signals. Conclusion presence induced sex-dependent, since mice. affected steroids their receptors